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1. (WO2018106862) ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/106862    International Application No.:    PCT/US2017/065011
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Fri Dec 08 00:59:59 CET 2017
IPC: C07K 16/28
A61K 39/00
Applicants: AGENUS INC.
LUDWIG INSTITUTE FOR CANCER RESEARCH LTD
MEMORIAL SLOAN KETTERING CANCER CENTER
Inventors: VAN DIJK, Marc
MUNDT, Cornelia, Anne
RITTER, Gerd
SCHAER, David
WOLCHOK, Jedd, David
MERGHOUB, Taha
WILSON, Nicholas, Stuart
SAVITSKY, David, Adam
FINDEIS, Mark, Arthur
UNDERWOOD, Dennis, John
CUILLEROT, Jean-Marie
PROSCURSHIM, Igor
SHEBANOVA, Olga
Title: ANTI-CTLA-4 ANTIBODIES AND METHODS OF USE THEREOF
Abstract:
The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.