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1. (WO2018106842) CYSTEINE PEPTIDE-ENABLED ANTIBODIES
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/106842    International Application No.:    PCT/US2017/064969
Publication Date: 14.06.2018 International Filing Date: 06.12.2017
IPC:
C07K 16/28 (2006.01), C07K 7/08 (2006.01), C07K 7/06 (2006.01)
Applicants: CITY OF HOPE [US/US]; 1500 E. Duarte Road Duarte, CA 91010 (US)
Inventors: WILLIAMS, John, C.; (US).
BZYMEK, Krzysztof; (US).
MA, Yuelong; (US).
HORNE, David; (US).
KING, Jeremy; (US)
Agent: HETZER-EGGER, Claudia; (US).
AZRIN, Linda, B.; (US).
ADAMS, Lisa; (US).
HETZER-EGGER, Claudia; (US).
BAUER, John, A.; (US)
Priority Data:
62/531,825 12.07.2017 US
62/430,848 06.12.2016 US
Title (EN) CYSTEINE PEPTIDE-ENABLED ANTIBODIES
(FR) ANTICORPS ACTIVÉS PAR UN PEPTIDE CYSTÉINE
Abstract: front page image
(EN)Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.
(FR)La présente invention concerne des anticorps monoclonaux fonctionnalisés (mAb) comprenant des fragments d'anticorps liés par covalence à un composé peptidique par l'intermédiaire d'une liaison disulfure. La liaison disulfure se situe entre une cystéine dans la région Fab de l'anticorps ou fragment de celui-ci et un fragment thiol d'acide aminé de chaîne latérale du composé peptidique. Les complexes formés par covalence, y compris ceux selon la présente invention, forment des compositions très stables et polyvalentes pour l'administration de médicaments et le diagnostic.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)