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1. (WO2018106753) METHODS AND COMPOSITIONS RELATING THE TREATMENT OF TUMORS

Pub. No.:    WO/2018/106753    International Application No.:    PCT/US2017/064809
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Thu Dec 07 00:59:59 CET 2017
IPC: A61K 48/00
C12N 15/63
A61P 35/00
Applicants: THE GENERAL HOSPITAL CORPORATION
Inventors: BRENNER, Gary, J.
FULCI, Giulia
AHMED, Sherif
Title: METHODS AND COMPOSITIONS RELATING THE TREATMENT OF TUMORS
Abstract:
Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiments, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.