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1. (WO2018106738) BRUSH-ARM STAR POLYMERS, CONJUGATES AND PARTICLES, AND USES THEREOF
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Pub. No.: WO/2018/106738 International Application No.: PCT/US2017/064784
Publication Date: 14.06.2018 International Filing Date: 05.12.2017
IPC:
A61K 47/60 (2017.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01)
[IPC code unknown for A61K 47/60]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
CHICKERING, Donald, E. III [US/US]; US
BLUME-JENSEN, Peter [DK/US]; US
ANDERSON, Jannik, N. [DK/US]; US
KOPESKY, Paul, Wayne [US/US]; US
SAUCIER-SAWTER, Jenniger, K. [US/US]; US
REITER, Lawrence, Alan [US/US]; US
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, MA 02139, US
XTUIT PHARMACEUTICALS, INC. [US/US]; 35 Gatehouse Drive Suite A1 Waltham, MA 02451, US
Inventors:
CHICKERING, Donald, E. III; US
BLUME-JENSEN, Peter; US
ANDERSON, Jannik, N.; US
KOPESKY, Paul, Wayne; US
SAUCIER-SAWTER, Jenniger, K.; US
REITER, Lawrence, Alan; US
JOHNSON, Jeremiah, A.; US
LIU, Jenny; US
GOLDER, Matthew, R.; US
Agent:
ZHANG, Wei; US
Priority Data:
62/430,25705.12.2016US
62/528,94005.07.2017US
62/529,43906.07.2017US
Title (EN) BRUSH-ARM STAR POLYMERS, CONJUGATES AND PARTICLES, AND USES THEREOF
(FR) POLYMÈRES EN ÉTOILE À BRAS EN BROSSE, CONJUGUÉS ET PARTICULES, ET LEURS UTILISATIONS
Abstract:
(EN) Described herein are macromonomers, conjugates comprising the macromonomers (also referred to alternatively as "BRUSH", or "BRUSH conjugates"), and brush arm star polymer particles comprising the conjugates (also referred to as "BASPs" or "BASP particles"), each further comprising an agent (e.g., one or more therapeutic agents, diagnostic agents, or targeting moieties), as well as starting materials (e.g., crosslinkers) and other components (e.g., degradation components) thereof, as well as pharmaceutical compositions and methods of making and using the same.
(FR) L'invention concerne des macromonomères, des conjugués les contenant (également appelés "BROSSE", ou "conjugués BROSSE"), et des particules de polymère en étoile à bras en brosse comprenant lesdits conjugués (également appelés "BASP" ou "particules BASP"), chacun comprenant en outre un agent (p. ex., un ou plusieurs agents thérapeutiques, agents de diagnostic, ou fragments de ciblage), ainsi que des matériaux de départ (p. ex., agents de réticulation) et d'autres composants (p. ex., composants de dégradation), ainsi que des compositions pharmaceutiques et leurs procédés de production et d'utilisation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)