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1. (WO2018106727) ENGINEERED NUCEIC ACID-TARGETING NUCLEIC ACIDS
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Pub. No.: WO/2018/106727 International Application No.: PCT/US2017/064771
Publication Date: 14.06.2018 International Filing Date: 05.12.2017
IPC:
C12N 15/10 (2006.01) ,C12N 15/11 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
CARIBOU BIOSCIENCES, INC. [US/US]; 2929 7th Street, Suite 105 Berkeley, CA 94710, US
Inventors:
DONOHOUE, Paul Daniel; US
MAY, Andrew Paul; US
Agent:
MCCLUNG, Barbara; US
FABIAN, Gary, R.; US
Priority Data:
15/371,18806.12.2016US
15/787,63018.10.2017US
Title (EN) ENGINEERED NUCEIC ACID-TARGETING NUCLEIC ACIDS
(FR) ACIDES NUCLÉIQUES MODIFIÉS CIBLANT DES ACIDES NUCLÉIQUES
Abstract:
(EN) The present disclosure provides engineered Class 2 CRISPR-Cas-associated discontinuous first-stem nucleic acid-targeting nucleic acids, nucleoprotein complexes comprising these nucleic acids, and compositions thereof. Nucleic acid sequences encoding the Class 2 CRISPR-Cas-associated discontinuous first-stem nucleic acid-targeting nucleic acids, as well as expression cassettes, vectors and cells comprising such nucleic acid sequences, are described. Also, methods are disclosed for making and using the Class 2 CRISPR-Cas-associated discontinuous first-stem nucleic acid-targeting nucleic acids, nucleoprotein complexes comprising such nucleic acids, and compositions thereof.
(FR) La présente invention concerne des acides nucléiques modifiés à première tige discontinue associés à CRISPR-Cas de classe 2 ciblant des acides nucléiques, des complexes nucléoprotéiniques comprenant ces acides nucléiques et des compositions correspondantes. L'invention concerne également des séquences d'acide nucléique codant pour lesdits acides nucléiques modifiés à première tige discontinue associés à CRISPR-Cas de classe 2 ciblant des acides nucléiques, ainsi que des cassettes d'expression, des vecteurs et des cellules comprenant de telles séquences d'acide nucléique. L'invention concerne également des procédés de production et d'utilisation des acides nucléiques modifiés à première tige discontinue associés à CRISPR-Cas de classe 2 ciblant des acides nucléiques, des complexes nucléoprotéiniques comprenant de tels acides nucléiques et des compositions correspondantes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)