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1. (WO2018106667) BROAD-SPECTRUM INHIBITORS OF FILOVIRUSES
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Pub. No.: WO/2018/106667 International Application No.: PCT/US2017/064675
Publication Date: 14.06.2018 International Filing Date: 05.12.2017
IPC:
A61K 31/551 (2006.01) ,C07D 401/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
551
having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
Applicants:
MICROBIOTIX, INC. [US/US]; One Innovation Dirve Worcester, MA 01605, US
ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. [US/US]; 1300 Morris Park Avenue Bronx, New York 10461, US
THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY [US/US]; 504 Scott Street Fort Detrick, Maryland 21702, US
Inventors:
BOWLIN, Terry, L.; US
MOIR, Donald, T.; US
CHANDRAN, Kartik; US
DYE, John M, Jr.; US
WILLIAMS, John, D.; US
ARON, Zachary, D.; US
BARBOR, Katherine, S.; US
LIVELY, Kelly, N.; US
NASH, Peter, J.; US
MILLS, Debra, M.; US
BASU, Arnab; US
Agent:
YANKWICH, Leon, R.; US
WESOLOWSKI, Michael, R.; US
YANKWICH, Leon, R.; US
BERKA, Thornas, R.; US
Priority Data:
62/430,20505.12.2016US
Title (EN) BROAD-SPECTRUM INHIBITORS OF FILOVIRUSES
(FR) INHIBITEURS À LARGE SPECTRE DE FILOVIRUS
Abstract:
(EN) The present invention is related to the development of therapeutics and prophylactics for the treatment and/or prevention of filovirus infection in humans and other mammals. A new class of small molecules is disclosed that inhibits the interaction of naturally processed (i.e., proteolytically cleaved) filovirus glycoprotein (GPCL) with its host receptor Niemann-Pick C 1 (NPCl) protein and thus block infection of host cells by filoviruses. Also disclosed are methods of using the small molecule inhibitors in the treatment/prevention of filovirus infection.
(FR) La présente invention se rapporte au développement d'agents thérapeutiques et prophylactiques pour le traitement et/ou la prévention d'une infection par filovirus chez l'homme et d'autres mammifères. La présente invention concerne une nouvelle classe de petites molécules qui inhibent l'interaction de la glycoprotéine de filovirus traitée naturellement (à savoir, clivée de manière protéolytique) (GPCL) avec sa protéine Niemann-Pick-C 1 (NPCl) de récepteur hôte et bloquent, ainsi, l'infection de cellules hôtes par des filovirus. La présente invention porte également sur des procédés d'utilisation des inhibiteurs à petites molécules dans le traitement/la prévention d'une infection par filovirus.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)