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1. (WO2018106648) LIPID-BASED PROBES FOR EXTRACELLULAR ISOLATION
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Pub. No.: WO/2018/106648 International Application No.: PCT/US2017/064634
Publication Date: 14.06.2018 International Filing Date: 05.12.2017
IPC:
C12N 15/10 (2006.01) ,C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
THE PENN STATE RESEARCH FOUNDATION [US/US]; 304 Old Main University Park, Pennsylvania 16802, US
Inventors:
ZHENG, Si-Yang; US
WAN, Yuan; US
CHENG, Gong; US
Agent:
BUCCA, Daniel; US
Priority Data:
62/430,16105.12.2016US
Title (EN) LIPID-BASED PROBES FOR EXTRACELLULAR ISOLATION
(FR) SONDES À BASE DE LIPIDES POUR L'ISOLEMENT EXTRACELLULAIRE
Abstract:
(EN) Lipid-based probes and systems therewith to capture and isolate extracellular vesicles from a sample are disclosed. The system can include a labelling probe-capture probe combination or an immobilized labelling probe on a surface of a substrate or a device including the immobilized labelling probe on a surface of a substrate. The labelling probe can include a lipid tail for insertion in the lipid bilayer membrane of extracellular vesicles. The labelling probe can further include a tag that can be readily combine with a capture probe or a high affinity component to bind to a substrate surface to immobilize the labelling probe, and a spacer between the lipid tail and tag or high affinity component.
(FR) L'invention concerne des sondes à base de lipides et des systèmes associés pour capturer et isoler des vésicules extracellulaires à partir d'un échantillon. Le système peut comprendre une combinaison de sonde de capture-sonde de marquage ou une sonde de marquage immobilisée sur la surface d'un substrat ou d'un dispositif comprenant la sonde de marquage immobilisée sur la surface d'un substrat. La sonde de marquage peut comprendre une queue lipidique destinée à être insérée dans la membrane bicouche lipidique des vésicules extracellulaires. La sonde de marquage peut en outre comprendre une étiquette qui peut se combiner facilement à une sonde de capture ou à un composant à haute affinité de liaison à une surface de substrat pour immobiliser la sonde de marquage, et un lieur entre la queue lipidique et l'étiquette ou le composant à haute affinité.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)