WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
1. (WO2018106628) COLONIC ORGANOIDS AND METHODS OF MAKING AND USING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/106628 International Application No.: PCT/US2017/064600
Publication Date: 14.06.2018 International Filing Date: 05.12.2017
IPC:
C07K 14/485 (2006.01) ,C07K 14/50 (2006.01) ,C07K 14/51 (2006.01) ,C12N 5/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
485
Epidermal growth factor (EGF) (urogastrone)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
50
Fibroblast growth factor (FGF)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
51
Bone morphogenic factor; Osteogenin; Osteogenic factor; Bone-inducing factor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants: CHILDREN'S HOSPITAL MEDICAL CENTER[US/US]; 3333 Burnett Avenue Cincinnati, OH 45229, US
Inventors: WELLS, James, M.; US
MUNERA, Jorge, Orlando; US
Agent: TEPE, Nicole, M.; US
GOLDSTEIN, Steven, J.; US
CONLEY, Scott, R.; US
ACHESON, Edwin, R.; US
SCHOEN, Ann, G.; US
Priority Data:
62/429,94805.12.2016US
62/478,96230.03.2017US
Title (EN) COLONIC ORGANOIDS AND METHODS OF MAKING AND USING SAME
(FR) ORGANOÏDES DU CÔLON ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
Abstract:
(EN) Disclosed herein are methods for the in vitro differentiation of a precursor cell into definitive endoderm, which may further be differentiated into a human colonic organoid (HCO), via modulation of signaling pathways. Further disclosed are HCOs and methods of using HCOs, which may be used, for example, for the HCOs may be used to determine the efficacy and/or toxicity of a potential therapeutic agent for a disease selected from colitis, colon cancer, polyposis syndromes, and/or irritable bowel syndrome.
(FR) L'invention concerne des procédés destinés à la différenciation in vitro d'une cellule précurseur en endoderme définitif, qui peut en outre être différenciée en un organoïde du côlon humain (HCO), par l'intermédiaire de la modulation de voies de signalisation. L'invention concerne en outre des HCO et des procédés d'utilisation des HCO, qui peuvent être utilisés, par exemple, pour déterminer l'efficacité et/ou la toxicité d'un agent thérapeutique potentiel pour une maladie choisie parmi la colite, le cancer du côlon, les syndromes de polypose et/ou le syndrome du côlon irritable.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)