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1. (WO2018106595) COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES

Pub. No.:    WO/2018/106595    International Application No.:    PCT/US2017/064507
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Tue Dec 05 00:59:59 CET 2017
IPC: A61K 35/17
C07K 16/28
C07K 16/30
Applicants: FATE THERAPEUTICS, INC.
Inventors: ROSEN, Jonathan
REZNER, Betsy, Denise
HARDY, Ian
PERALTA, Eigen
Title: COMPOSITIONS AND METHODS FOR IMMUNE CELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES
Abstract:
Compounds that either produced a higher proportion or greater absolute number of phenotypically identified naive, stem cell memory, central memory T cells, adaptive NK cells, and type I NKT cells are identified. Compositions and methods for modulating immune cells including T, NK, and NKT cells for adoptive cell therapies with improved efficacy are provided.