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1. (WO2018106578) ORAL E. COLI VECTOR-BASED VACCINE FOR PREVENTION OF COCCIDIOSIS IN POULTRY
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Pub. No.: WO/2018/106578 International Application No.: PCT/US2017/064456
Publication Date: 14.06.2018 International Filing Date: 04.12.2017
IPC:
A61K 39/00 (2006.01) ,A61K 39/108 (2006.01) ,A61K 39/09 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
108
Escherichia; Klebsiella
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
09
Streptococcus
Applicants:
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE [US/US]; 1400 Independence Ave. S.W. Washington, District of Columbia 20250, US
US BIOLOGIC [US/US]; US BIOLOGIC 20 Dudley, Suite 900 Memphis, Tennessee 38103-4904, US
Inventors:
LILLEHOJ, Hyun S.; US
KIM, Woohyun; US
PRZYBYSZEWSKI, Chris; US
ZATECHKA, D. Steven; US
Agent:
GOLDBERG, Joshua B.; US
Priority Data:
15/828,77801.12.2017US
62/429,94105.12.2016US
Title (EN) ORAL E. COLI VECTOR-BASED VACCINE FOR PREVENTION OF COCCIDIOSIS IN POULTRY
(FR) VACCIN ORAL À BASE DU VECTEUR E. COLI, DESTINÉ À LA PRÉVENTION DE LA COCCIDIOSE CHEZ LES VOLAILLES
Abstract:
(EN) The invention relates to recombinant vaccines capable of presenting all, or antigenic portions of, the Eimeria tenella 3-1e, or profilin. Also provided are methodologies of using the vaccines for oral administration to poultry and other targets in the control of coccidiosis. In particular embodiments, recombinant host cells, such as E. coli, expressing all or part of the 3-1e antigen, are provided that can be used as whole-cell vaccines. In some instances, the native 3-1e protein utilized in the vaccines presented herein is molecularly manipulated.
(FR) L'invention concerne des vaccins recombinants aptes à présenter l'ensemble de la protéine Eimeria tenella 3-1e, ou des parties antigéniques de cette dernière, ou de la profiline. L'invention concerne également des procédés d'utilisation des vaccins destinés à une administration orale à des volailles et à d'autres cibles dans le contrôle de la coccidiose. Dans des modes de réalisation particuliers, l'invention concerne des cellules hôtes recombinantes, telles que E. coli, exprimant l'ensemble de l'antigène 3-1e, ou une partie de ce dernier, qui peuvent être utilisées comme vaccins à cellules entières. Dans certains cas, la protéine 3-1e native utilisée dans les vaccins présentés dans la description est manipulée moléculairement.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)