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1. (WO2018106280) CONTROLLED-RELEASE COMPOSITIONS OF MELATONIN COMBINED WITH SEDATIVE AND/OR ANALGESIC INGREDIENTS

Pub. No.:    WO/2018/106280    International Application No.:    PCT/US2017/031012
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Fri May 05 01:59:59 CEST 2017
IPC: A61K 9/20
A61K 31/4045
A61K 36/76
A61K 36/84
Applicants: PHYSICIAN'S SEAL, LLC
Inventors: SHAH, Syed M.
HASSAN, Daniel
DIORIO, Christopher
HASSAN, Fred
Title: CONTROLLED-RELEASE COMPOSITIONS OF MELATONIN COMBINED WITH SEDATIVE AND/OR ANALGESIC INGREDIENTS
Abstract:
Controlled-release therapeutic compositions including melatonin combined with sedative and/or analgesic ingredients are described. The compositions have a solid core including melatonin in an acidified polymeric matrix. A sedative ingredient such as a GABA receptor agonist may also be in the acidified polymeric matrix. The composition may include an expedited release portion providing a burst release of active ingredients and a sustained release portion providing a sustained release of active ingredients.