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1. (WO2018106273) COLLAGEN TARGETING NANOFIBERS AND NANOSHEETS
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Pub. No.: WO/2018/106273 International Application No.: PCT/US2017/019724
Publication Date: 14.06.2018 International Filing Date: 27.02.2017
IPC:
A61K 49/00 (2006.01) ,A61K 49/14 (2006.01) ,A61K 47/48 (2006.01) ,C07K 14/78 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
14
Peptides, e.g. proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
78
Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
Applicants:
UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 615 Arapeen Drive Suite 310 Salt Lake City, UT 84108, US
Inventors:
YU, S., Michael; US
LI, Yang; US
SAN, Boi, Hoa; US
Agent:
MARTY, Scott, D.; US
KATZ, Mitchell, A.; US
CHOI, Wendy, A.; US
BROWN, Charley, F; US
MEADOWS, Brian, C.; US
Priority Data:
62/430,61706.12.2016US
Title (EN) COLLAGEN TARGETING NANOFIBERS AND NANOSHEETS
(FR) NANOFIBRES ET NANOFEUILLES CIBLANT LE COLLAGÈNE
Abstract:
(EN) Disclosed are peptide conjugates comprising a (FKFE)2 (SEQ ID NO: l) beta-sheet forming peptide; a spacer moiety; and a collagen hybridizing peptide. Disclosed are peptide conjugates comprising a (FKFE)2 (SEQ ID NO: l) beta-sheet forming peptide; a spacer moiety; and a collagen hybridizing peptide, wherein the collagen hybridizing peptide comprises the sequence of at least (GXY)n (SEQ ID NO:77), wherein G is glycine, wherein X and Y are any amino acid, and wherein n is at least 3. Disclosed are nanofibers comprising two or more of the disclosed peptide conjugates. Disclosed are nanosheets comprising two or more of the disclosed nanofibers. Disclosed are methods of detecting denatured collagen in a sample comprising contacting a composition comprising the one of the disclosed peptide conjugates, and detecting the presence or absence of binding of the peptide conjugate to denatured collagen, wherein the presence of binding indicates the presence of denatured collagen.
(FR) La présente invention concerne des conjugués peptidiques comprenant un peptide de formation de feuillet bêta (FKFE)2 (SEQ ID NO: l) ; un fragment d’espaceur ; et un peptide d’hybridation de collagène. La présente invention concerne des conjugués peptidiques comprenant un peptide de formation de feuillet bêta (FKFE)2 (SEQ ID NO: l) ; une fraction d’espaceur ; et un peptide d’hybridation de collagène, le peptide d’hybridation de collagène comprenant la séquence d’au moins (GXY) n (SEQ ID NO: 77), où G est la glycine, X et Y étant n’importe quel acide aminé, et n étant au moins 3. L’invention concerne des nanofibres comprenant deux ou plus de deux des conjugués peptidiques de l’invention. L’invention concerne des nanofeuilles comprenant deux ou plus de deux des nanofibres de l’invention. L’invention concerne des procédés de détection de collagène dénaturé dans un échantillon comprenan la mise en contact d’une composition comprenant l’un des conjugués peptidiques de l’invention, et la détection de la présence ou l’absence de liaison du conjugué peptidique au collagène dénaturé, la présence d’une liaison indiquant la présence de collagène dénaturé.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)