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1. (WO2018106132) MICROFLUIDIC DEVICE FOR CELL CULTURE IN GRADIENT OF BIOACTIVE SUBSTANCE
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Pub. No.: WO/2018/106132 International Application No.: PCT/PL2017/000122
Publication Date: 14.06.2018 International Filing Date: 08.12.2017
IPC:
C12M 3/00 (2006.01) ,C12M 1/00 (2006.01) ,B01L 3/00 (2006.01) ,B81B 7/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
3
Tissue, human, animal or plant cell, or virus culture apparatus
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B PERFORMING OPERATIONS; TRANSPORTING
81
MICRO-STRUCTURAL TECHNOLOGY
B
MICRO-STRUCTURAL DEVICES OR SYSTEMS, e.g. MICRO-MECHANICAL DEVICES
7
Micro-structural systems
Applicants:
POLITECHNIKA WROCŁAWSKA [PL/PL]; Wybrzeże St. Wyspiańskiego 27 50-370 Wrocław, PL
UNIWERSYTET MEDYCZNY IM. PIASTÓW ŚLĄSKICH [PL/PL]; Wybrzeże L. Pasteura 1 50-367 Wrocław, PL
Inventors:
SZAFRAN, Roman; PL
GĄSIOROWSKI, Kazimierz; PL
GĘBCZAK, Katarzyna; PL
WIATRAK, Benita; PL
Priority Data:
P.41975409.12.2016PL
Title (EN) MICROFLUIDIC DEVICE FOR CELL CULTURE IN GRADIENT OF BIOACTIVE SUBSTANCE
(FR) DISPOSITIF MICROFLUIDIQUE DE CULTURE DE CELLULES EN GRADIENT DE SUBSTANCE BIOACTIVE
Abstract:
(EN) A multilayer microfluidic device for cell culture in the gradient of a bioactive substance characterised by three layers and two protective cups (3) of tanks, the top layer being a cover (6), which contains tanks of fluids feeding the culture chambers (1), reference points (4) and a millimetre graduation (5); in the middle functional layer (7), made of adhesive film, there is a set of channels serving as culture and indicator chambers (2) with semi-circular ends (8), at least one of which is intended for cell culture in concentration gradient of the active substance (culture chamber), one for cell culture without an active agent (blind test) and one to develop a concentration profile of the indicator substance (indicator chamber); and the bottom layer is the base (9).
(FR) La présente invention concerne un dispositif microfluidique multicouche destiné à la culture de cellules dans le gradient d’une substance bioactive caractérisé par trois couches et deux coupelles de protection (3) de cuves, la couche supérieure étant un couvercle (6), qui contient les cuves de liquides alimentant les chambres de culture (1), des points de référence (4) et une graduation en millimètres (5) ; dans la couche fonctionnelle médiane (7), constituée de film adhésif, est présent un ensemble de canaux servant de chambres de culture et indicatrices (2) avec des extrémités semi-circulaires (8), dont au moins l’un est prévu pour la culture de cellules en gradient de concentration de la substance active (chambre de culture), l’un pour la culture de cellules sans agent actif (test à l’aveugle) et l’un pour développer un profil de concentration de la substance indicatrice (chambre indicatrice) ; et la couche inférieure est la base (9).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Polish (PL)