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1. (WO2018106118) TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA

Pub. No.:    WO/2018/106118    International Application No.:    PCT/NL2017/050826
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: A61K 45/06
A61K 31/4375
A61P 35/00
Applicants: FLOHIL, Jacob Ary
Inventors: FLOHIL, Jacob Ary
Title: TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA
Abstract:
The present invention relates to an inhibitor of MELK and/or ROR2, preferably for use in the treatment of diffuse intrinsic pontine glioma (DIPG), wherein said DIPG is preferably characterized by overexpression of MELK and/or overexpression of ROR2. The inhibitor may be combined with a P-glycoprotein inhibitor, an Abcb1a inhibitor, Abcb1b inhibitor, mannitol, or an Abcg2 inhibitor.