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1. (WO2018106112) MULTICYCLIC PEPTIDES AND METHODS FOR THEIR PREPARATION
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Pub. No.: WO/2018/106112 International Application No.: PCT/NL2017/050820
Publication Date: 14.06.2018 International Filing Date: 06.12.2017
IPC:
C07K 1/04 (2006.01) ,C07K 1/107 (2006.01) ,C07K 7/56 (2006.01) ,C07K 7/64 (2006.01) ,C40B 30/04 (2006.01) ,G01N 33/543 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
04
on carriers
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
107
by chemical modification of precursor peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50
Cyclic peptides containing at least one abnormal peptide link
54
with at least one abnormal peptide link in the ring
56
the cyclisation not occurring through 2,4-diamino-butanoic acid
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
64
Cyclic peptides containing only normal peptide links
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30
Methods of screening libraries
04
by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
Applicants:
STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN [NL/NL]; Van Vollenhovenlaan 661 3527 JP Utrecht, NL
UNIVERSITEIT VAN AMSTERDAM [NL/NL]; NL
Inventors:
RICHELLE, Gaston Julia Johannes; NL
STREEFKERK, Dieuwertje Emma; NL
VAN MAARSEVEEN, Jan Herman; NL
TIMMERMAN, Peter; NL
Agent:
JANSEN, C. M.; V.O. Carnegieplein 5 2517 KJ Den Haag, NL
Priority Data:
16202466.506.12.2016EP
17189088.201.09.2017EP
Title (EN) MULTICYCLIC PEPTIDES AND METHODS FOR THEIR PREPARATION
(FR) PEPTIDES MULTICYCLIQUES ET LEURS PROCÉDÉS DE PRÉPARATION
Abstract:
(EN) The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.
(FR) L'invention concerne des procédés de préparation d'un composé comprenant un peptide fixé à un échafaudage moléculaire ce qui permet à de multiples boucles peptidiques d'être formées, l'invention concerne également des composés qui peuvent être obtenus avec de tels procédés et leurs utilisations.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)