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1. (WO2018105921) USE OF LEUCINE-ZIPPER PROTEIN FOR DIAGNOSIS OR TREATMENT OF FATTY LIVER

Pub. No.:    WO/2018/105921    International Application No.:    PCT/KR2017/013154
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Tue Nov 21 00:59:59 CET 2017
IPC: A61K 48/00
A61K 39/395
G01N 33/68
G01N 33/50
C12Q 1/68
A61K 39/00
Applicants: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
고려대학교 산학협력단
Inventors: KO, Jesang
고제상
KANG, Min-Soo
강민수
Title: USE OF LEUCINE-ZIPPER PROTEIN FOR DIAGNOSIS OR TREATMENT OF FATTY LIVER
Abstract:
The present invention relates to a use of leucine-zipper protein for diagnosis or treatment of fatty liver. According to the present invention, it could be confirmed that a particular fragment present at the leucine-zipper protein, especially, the N-terminal region thereof, plays an important role in the lipid metabolism in liver tissue by regulating transcriptional activity of Apolipoprotein A4, and therefore, the protein of the present invention or a fragment thereof can be utilized as a target for diagnosis, prevention, or treatment of fatty liver.