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1. (WO2018104967) MAPPING PROTEIN BINDING SITES AND CONFORMATIONAL EPITOPES USING CYSTEINE LABELLING AND SURFACE DISPLAY LIBRARY

Pub. No.:    WO/2018/104967    International Application No.:    PCT/IN2017/050581
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: G01N 33/68
C12Q 1/68
Applicants: INDIAN INSTITUTE OF SCIENCE
Inventors: VARADARAJAN, Raghavan
NAJAR, Tariq Ahmad
DATTA, Rohini
Title: MAPPING PROTEIN BINDING SITES AND CONFORMATIONAL EPITOPES USING CYSTEINE LABELLING AND SURFACE DISPLAY LIBRARY
Abstract:
The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.