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1. (WO2018104954) PROCESS FOR THE PREPARATION OF N-(4-(6,7-DIMETHOXYQUINOLIN-4-YLOXY) PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1, 1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE AND ITS POLYMORPHS THEREOF
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Pub. No.: WO/2018/104954 International Application No.: PCT/IN2017/000139
Publication Date: 14.06.2018 International Filing Date: 06.12.2017
IPC:
C07D 215/233 (2006.01) ,A61K 31/47 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Oxygen atoms
22
attached in position 2 or 4
233
only one oxygen atom which is attached in position 4
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
Applicants: THIRUMALAI RAJAN, Srinivasan[IN/IN]; IN
ESWARAIAH, Sajja[IN/IN]; IN
VENKATA PANAKALA RAO, Gogulapati[IN/IN]; IN
RAJESHWAR REDDY, Sagyam[IN/IN]; IN
SHYAM KIRAN BABU, Gandham[IN/IN]; IN
RAJESHAM, Boge[IN/IN]; IN
MSN LABORATORIES PRIVATE LIMITED, R&D CENTER[IN/IN]; Plot No. 12, Phase-IV, Sy No. 119 to 140, 258, 275 to 280, IDA, Pashamylaram (Vill), Patancheru (Mdl) Medak (Dist), Telangana 502 307, IN
Inventors: THIRUMALAI RAJAN, Srinivasan; IN
ESWARAIAH, Sajja; IN
VENKATA PANAKALA RAO, Gogulapati; IN
RAJESHWAR REDDY, Sagyam; IN
SHYAM KIRAN BABU, Gandham; IN
RAJESHAM, Boge; IN
Common
Representative:
THIRUMALAI RAJAN, Srinivasan; IN
Priority Data:
20164104176707.12.2016IN
20174102099815.06.2017IN
Title (EN) PROCESS FOR THE PREPARATION OF N-(4-(6,7-DIMETHOXYQUINOLIN-4-YLOXY) PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1, 1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE AND ITS POLYMORPHS THEREOF
(FR) PROCÉDÉ DE PRÉPARATION DE N-(4-(6,7-DIMÉTHOXYQUINOLIN-4-YLOXY) PHÉNYL)-N'-(4-FLUOROPHÉNYL)CYCLOPROPANE-1, 1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE ET SES POLYMORPHES
Abstract:
(EN) The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N' -( 4-fluorophenyl)cyclopropane-1, 1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural.
(FR) La présente invention concerne un procédé de préparation d'un composé de N-(4-(6,7-diméthoxy quinolin-4-yloxy)phényl)-N' -( 4-fluorophényl)cyclopropane-1, 1-dicarboxamide (S)-malate de formule -1a et ses polymorphes, représenté par la structure suivante.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)