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1. WO2018104954 - PROCESS FOR THE PREPARATION OF N-(4-(6,7-DIMETHOXYQUINOLIN-4-YLOXY) PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1, 1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE AND ITS POLYMORPHS THEREOF

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Publication Number WO/2018/104954
Publication Date 14.06.2018
International Application No. PCT/IN2017/000139
International Filing Date 06.12.2017
IPC
C07D 215/233 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
22attached in position 2 or 4
233only one oxygen atom which is attached in position 4
A61K 31/47 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
CPC
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07D 215/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
C07D 215/233
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
22attached in position 2 or 4
233only one oxygen atom which is attached in position 4
Applicants
  • MSN LABORATORIES PRIVATE LIMITED, R&D CENTER [IN]/[IN]
  • THIRUMALAI RAJAN, Srinivasan [IN]/[IN]
  • ESWARAIAH, Sajja [IN]/[IN]
  • VENKATA PANAKALA RAO, Gogulapati [IN]/[IN]
  • RAJESHWAR REDDY, Sagyam [IN]/[IN]
  • SHYAM KIRAN BABU, Gandham [IN]/[IN]
  • RAJESHAM, Boge [IN]/[IN]
Inventors
  • THIRUMALAI RAJAN, Srinivasan
  • ESWARAIAH, Sajja
  • VENKATA PANAKALA RAO, Gogulapati
  • RAJESHWAR REDDY, Sagyam
  • SHYAM KIRAN BABU, Gandham
  • RAJESHAM, Boge
Common Representative
  • THIRUMALAI RAJAN, Srinivasan
Priority Data
20164104176707.12.2016IN
20174102099815.06.2017IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF N-(4-(6,7-DIMETHOXYQUINOLIN-4-YLOXY) PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1, 1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE AND ITS POLYMORPHS THEREOF
(FR) PROCÉDÉ DE PRÉPARATION DE N-(4-(6,7-DIMÉTHOXYQUINOLIN-4-YLOXY) PHÉNYL)-N'-(4-FLUOROPHÉNYL)CYCLOPROPANE-1, 1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE ET SES POLYMORPHES
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Abstract
(EN) The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N' -( 4-fluorophenyl)cyclopropane-1, 1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural.
(FR) La présente invention concerne un procédé de préparation d'un composé de N-(4-(6,7-diméthoxy quinolin-4-yloxy)phényl)-N' -( 4-fluorophényl)cyclopropane-1, 1-dicarboxamide (S)-malate de formule -1a et ses polymorphes, représenté par la structure suivante.
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