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1. (WO2018104935) CRYOPRESERVATION METHOD OF BIOLOGICAL SPECIMEN

Pub. No.:    WO/2018/104935    International Application No.:    PCT/IL2017/051313
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Wed Dec 06 00:59:59 CET 2017
IPC: A01N 1/02
Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventors: BRASLAVSKY, Ido
YASHUNSKY, Victor
BEIN, Amir
BAHARI, Liat
SCHWARTZ, Betty
Title: CRYOPRESERVATION METHOD OF BIOLOGICAL SPECIMEN
Abstract:
The invention relates to a method for cryopreserving a biological sample adhered to a substrate. The method of the invention comprises freezing of adherent cells and/or intact multicellular ensembles, without detaching them from the substrate or from each other. This method utilizes a directional freezing approach, which enables control over ice crystals shape, ice growth rate and position, which have a crucial impact on the physiological revival of the sample upon thawing. The invention further relates to samples cryopreserved according to the method of the invention.