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1. (WO2018104909) DNA METHYLATION PROFILING FOR T-CELL IMMUNOTHERAPY

Pub. No.:    WO/2018/104909    International Application No.:    PCT/IB2017/057733
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Fri Dec 08 00:59:59 CET 2017
IPC: C12Q 1/68
C12N 5/0783
A61K 31/7068
A61K 35/17
Applicants: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventors: YOUNGBLOOD, Benjamin
ABDELSAMED, Hossam
GHONEIM, Hazem
Title: DNA METHYLATION PROFILING FOR T-CELL IMMUNOTHERAPY
Abstract:
Provided herein are methods and compositions for modulating T-cell activity by altering DNA methylation status. Altering the methylation status of CD8+ T cells can prevent T-cell exhaustion and maintain effector functions during sustained antigen exposure. The methods and compositions can be used to treat symptoms of chronic infections and cancer. Further, the methods and compositions relate to predicting T-cell activity by measuring the methylation status of specific memory cell methylation markers and using the markers to identify and separate populations of CD8 T cell having desired T cell activity. The memory cell methylation markers can further be used to identify subjects with chronic infections or cancer that would benefit from personalized therapy, including immune checkpoint blockade therapy.