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1. (WO2018104538) RNA FOR TREATMENT OR PROPHYLAXIS OF A LIVER DISEASE

Pub. No.:    WO/2018/104538    International Application No.:    PCT/EP2017/082103
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: A61K 48/00
A61P 1/16
Applicants: CUREVAC AG
Inventors: HORSCROFT, Nigel
PÖNISCH, Marion
WEINL, Christine
Title: RNA FOR TREATMENT OR PROPHYLAXIS OF A LIVER DISEASE
Abstract:
The present invention relates to an RNA suitable for treatment or prophylaxis of liver diseases. In particular, the present invention provides an RNA encoding at least one peptide or protein selected from the group consisting of an extracellular matrix protease, CCAAT/enhancer-binding protein alpha (CEBPA), TNF-related apoptosis-inducing ligand (TRAIL), Hepatocyte Growth Factor (HGF), hepatocyte nuclear factor 4 alpha (HNF4A), fibroblast growth factor 21 (FGF21), opioid growth factor receptor-like 1 (OGFRL1), Relaxin 1 (RLN1), Relaxin 2 (RLN2) and Relaxin 3 (RLN3), or a fragment or a variant of any of these peptides or proteins. The present invention concerns said RNA as well as compositions and kits comprising the RNA. Furthermore, the present invention relates to the RNA, compositions or kits as disclosed herein for use as a medicament, in particular for treatment or prophylaxis of a liver disease. The present invention also provides the use of the RNA, compositions or kits as disclosed herein for increasing the expression of said encoded protein, in particular in gene therapy.