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|1. (WO2018104492) NUCLEIC ACID-BASED ASSEMBLY AND USE THEREOF IN CANCER THERAPY|
|Applicants:||RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
|Title:||NUCLEIC ACID-BASED ASSEMBLY AND USE THEREOF IN CANCER THERAPY|
The present invention relates to a nucleic acid-based assembly comprising: at least one nucleic acid aptamer, and at least one nucleic acid motif designed to physically capture a drug. The nucleic acid motif may comprise one or more photo-responsive moieties that effect the release of the drug upon irradiation. The aptamer and the nucleic acid motif each can be covalently linked to one or more lipids, and the lipid- modified aptamer and nucleic acid motif may form the assembly through noncovalent interaction. The invention further relates to use of the nucleic acid-based assembly in the treatment of cancer.