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1. (WO2018104492) NUCLEIC ACID-BASED ASSEMBLY AND USE THEREOF IN CANCER THERAPY

Pub. No.:    WO/2018/104492    International Application No.:    PCT/EP2017/081933
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Fri Dec 08 00:59:59 CET 2017
IPC: A61K 47/56
A61K 47/54
A61K 47/69
A61K 9/107
A61K 31/704
A61P 35/00
Applicants: RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
Inventors: FAMULOK, Michael
PRUSTY, Deepak
ADAM, Volker
IRSEN, Stephan
Title: NUCLEIC ACID-BASED ASSEMBLY AND USE THEREOF IN CANCER THERAPY
Abstract:
The present invention relates to a nucleic acid-based assembly comprising: at least one nucleic acid aptamer, and at least one nucleic acid motif designed to physically capture a drug. The nucleic acid motif may comprise one or more photo-responsive moieties that effect the release of the drug upon irradiation. The aptamer and the nucleic acid motif each can be covalently linked to one or more lipids, and the lipid- modified aptamer and nucleic acid motif may form the assembly through noncovalent interaction. The invention further relates to use of the nucleic acid-based assembly in the treatment of cancer.