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1. (WO2018104426) FLEXIBILITY MEASUREMENTS OF INJECTABLE GELS

Pub. No.:    WO/2018/104426    International Application No.:    PCT/EP2017/081783
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Fri Dec 08 00:59:59 CET 2017
IPC: G01N 11/16
A61K 31/728
G01N 11/00
Applicants: NESTLÉ SKIN HEALTH SA
Inventors: ÖHRLUND, Åke
KARLSSON, Morgan
Title: FLEXIBILITY MEASUREMENTS OF INJECTABLE GELS
Abstract:
The present invention provides a process for evaluating rheological characteristics of an injectable gel comprising measuring the flexibility, wherein the flexibility is evaluated by measuring the strain at the crossover point of the amplitude sweep. As an example, the process may comprise subjecting an injectable gel to oscillating mechanical stresses to determine G' and G" as a function of strain (γ) in an amplitude sweep, determining the crossover point as the point at which G' and G" have the same value, determining the strain Ycrass at the crossover point, and determining the flexibility of the injectable gel as Ycrass or proportional to Ycross. The present invention further provides a method of comparison of dermal fillers by measuring their flexibility and a method of evaluation of dermal filler behavior in human skin by measuring the flexibility according to the previous claims.