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1. (WO2018104419) NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/104419    International Application No.:    PCT/EP2017/081768
Publication Date: 14.06.2018 International Filing Date: 07.12.2017
IPC:
C07D 413/14 (2006.01), A61K 31/4439 (2006.01), A61K 31/501 (2006.01), A61P 25/28 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department Little Falls, New Jersey 07424 (US) (US only)
Inventors: BUETTELMANN, Bernd; (CH).
CECERE, Giuseppe; (CH).
FASCHING, Bernhard; (CH).
GROEBKE ZBINDEN, Katrin; (CH).
HERNANDEZ, Maria-Clemencia; (CH).
KNUST, Henner; (CH).
KOBLET, Andreas; (CH).
PINARD, Emmanuel; (CH).
THOMAS, Andrew; (CH)
Agent: BERNARD, Guillaume; (CH)
Priority Data:
16202889.8 08.12.2016 EP
Title (EN) NEW ISOXAZOLYL ETHER DERIVATIVES AS GABA A ALPHA5 PAM
(FR) NOUVEAUX DÉRIVÉS D'ÉTHER ISOXAZOLYLE EN TANT QUE GABA A ALPHA5 PAM
Abstract: front page image
(EN)The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as described herein, compositions including the compounds and methods of using the compounds.
(FR)L'invention porte sur de nouveaux composés répondant à la formule générale (I), dans laquelle R1, R2, R3, R4, R5, R6, X, Y, et Z sont tels que décrits dans la description. L'invention porte également sur des compositions comprenant ces composés et sur leurs procédés d'utilisation.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)