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1. (WO2018103761) PEPTIDES, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
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Pub. No.: WO/2018/103761 International Application No.: PCT/CN2017/118520
Publication Date: 14.06.2018 International Filing Date: 26.12.2017
IPC:
C07K 7/06 (2006.01) ,C07K 7/08 (2006.01) ,A61K 38/08 (2006.01) ,A61K 38/10 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10
Peptides having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
唐琼瑶 TANG, Qiongyao [CN/CN]; CN
徐州医科大学 XUZHOU MEDICAL UNIVERSITY [CN/CN]; 中国江苏省徐州市 铜山路209号张赭 ZHANG, Zhe No. 209 Tongshan Road Xuzhou, Jiangsu 221004, CN
西南医科大学附属医院 THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIVERSITY [CN/CN]; 中国四川省泸州市 太平街25号唐明希 TANG, Mingxi No. 25 Taiping Street Luzhou, Sichuan 646000, CN
Inventors:
唐琼瑶 TANG, Qiongyao; CN
张赭 ZHANG, Zhe; CN
唐明希 TANG, Mingxi; CN
Agent:
南京禹为知识产权代理事务所(特殊普通合伙) YUV (NANJING) INTELLECTUAL PROPERTY FIRM (SPECIAL GP); 中国江苏省南京市 江宁区利源南路55号牛首工业园1号楼B栋2楼王晓东 WANG, Xiaodong Floor 2, Building B, Building 1, Niu Shou Industrial Park No.55 Lee Yuen South Road, Jiangning District Nanjing, Jiangsu 211100, CN
Priority Data:
201611128087.609.12.2016CN
Title (EN) PEPTIDES, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
(FR) PEPTIDES, COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS CORRESPONDANTES
(ZH) 一组肽及其药物组合物和应用
Abstract:
(EN) Provided are peptides, and pharmaceutical compositions and uses thereof. The peptides are as shown in the sequence listing, and are amino acid sequences having an analgesic effect, or pharmaceutically acceptable salts thereof. The two cysteine at the head end and the tail end of a peptide provided forms a ring. The pharmacophore (domain) having the analgesic effect in the GsMTx-4 polypeptide is determined by comparing the sequences of multiple polypeptides containing cysteine knots (ICK), such as GsMTx-4 and GsMTX-2, and by means of behavioral measurement on rat pain models.
(FR) L'invention concerne des peptides, des compositions pharmaceutiques et des utilisations correspondantes. Les peptides sont tels que présentés dans la liste de séquences, et sont des séquences d'acides aminés ayant un effet analgésique, ou des sels pharmaceutiquement acceptables de ceux-ci. Les deux cystéines au niveau de l'extrémité de tête et de l'extrémité de queue d'un peptide de la présente invention forment un anneau. Le pharmacophore (domaine) ayant l'effet analgésique dans le polypeptide GsMTx-4 est déterminé par comparaison des séquences de multiples polypeptides contenant des nœuds de cystéine (ICK), tels que GsMTx-4 et GsMTx-2 et au moyen d'une mesure comportementale sur des modèles de douleur de rat.
(ZH) 提供了一组肽及其药物组合物和应用,其中肽如序列表所示,其是具有镇痛作用的氨基酸序列或它们药学上可以接受的盐。提供肽的首端和末端的两个半胱氨酸形成环。通过比较GsMTx-4、GsMTX-2等多种含半胱氨酸结(ICK)的多肽序列,并通过对大鼠疼痛模型的行为学检测,确定了在GsMTx-4多肽中起镇痛作用的药效团(结构域)。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)