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1. (WO2018103759) SELF-ASSEMBLED DRUG-LOADING SYSTEM AND PREPARATION METHOD THEREFOR

Pub. No.:    WO/2018/103759    International Application No.:    PCT/CN2017/116061
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Fri Dec 15 00:59:59 CET 2017
IPC: A61K 45/06
A61K 9/19
A61K 41/00
A61K 31/337
A61K 31/12
A61K 31/4745
A61P 35/00
Applicants: JIANGXI KEWEI COLLABORATIVE INNOVATION PHARMACEUTICAL CO., LTD.
江西科维协同创新药物有限公司
Inventors: SHEN, Youqing
申有青
HU, Shiqi
胡诗琪
Title: SELF-ASSEMBLED DRUG-LOADING SYSTEM AND PREPARATION METHOD THEREFOR
Abstract:
Disclosed are a self-assembled drug-loading system containing a hydrophilic phototherapeutic drug and a hydrophobic chemotherapeutic drug, a preparation method therefor and the use thereof for preparing an anti-tumour drug. The self-assembled drug-loading system is a water-soluble complex or water-dispersible nanoparticles formed by means ofπ-π interaction or hydrophobic interaction between the phototherapeutic drug and the chemotherapeutic drug, wherein the molar ratio of the phototherapeutic drug to the chemotherapeutic drug is 2 : 1 to 1 : 10.