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1. (WO2018103726) CRYSTAL FORM OF BROMODOMAIN PROTEIN INHIBITOR DRUG, PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/103726 International Application No.: PCT/CN2017/115143
Publication Date: 14.06.2018 International Filing Date: 08.12.2017
IPC:
C07D 413/06 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/517 (2006.01) ,A61P 9/10 (2006.01) ,A61P 9/00 (2006.01) ,A61P 3/10 (2006.01) ,A61P 5/38 (2006.01)
Applicants: CRYSTAL PHARMACEUTICAL (SUZHOU) CO., LTD.[CN/CN]; B4-301, Biobay, 218 Xinghu Street, Industrial Park Suzhou, Jiangsu 215123, CN
Inventors: CHEN, Minhua; CN
ZHANG, Yanfeng; CN
ZHAI, Xiaoting; CN
YAN, Kaiqiang; CN
ZHANG, Xiaoyu; CN
Agent: LINDA LIU & PARTNERS; F16 Tower C, Beijing Global Trade Center, 36 North Third Ring East Road, Dongcheng District Beijing 100013, CN
Priority Data:
201611131698.609.12.2016CN
201611229263.527.12.2016CN
Title (EN) CRYSTAL FORM OF BROMODOMAIN PROTEIN INHIBITOR DRUG, PREPARATION METHOD AND USE THEREOF
(FR) FORME CRISTALLINE D'UN MÉDICAMENT INHIBITEUR DE PROTÉINE DE BROMODOMAINE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 一种溴结构域蛋白抑制剂药物的晶型及其制备方法和用途
Abstract: front page image
(EN) Provided are a crystal form of a bromodomain protein inhibitor 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one represented by Formula I, a preparation method and a use thereof. The present invention belongs to the field of medicine. The crystal forms are crystal form CS2, crystal form CS8, crystal form CS13, crystal form CS20, crystal form CS1, crystal form CS7, crystal form CS9, crystal form CS11, and crystal form CS4, and can be used to prepare drugs for treating cardiovascular, cholesterol, or lipid-related disorders.
(FR) L'invention concerne une forme cristalline d'un inhibiteur de protéine de bromodomaine 2-[4-(2-hydroxyéthoxy)-3,5-diméthylphényl]-5,7-diméthoxyquinazolin-4(3H)-one représenté par la formule I, un procédé de préparation et une utilisation de celui-ci. L'invention concerne le domaine de la médecine. Les formes cristallines sont la forme cristalline CS2, la forme cristalline CS8, la forme cristalline CS13, la forme cristalline CS20, la forme cristalline CS1, la forme cristalline CS7, la forme cristalline CS9, la forme cristalline CS11, et la forme cristalline CS4 et peut être utilisée pour préparer des médicaments pour le traitement de troubles cardiovasculaires, de cholestérol ou de troubles liés aux lipides.
(ZH) 一种式I所示的溴结构域蛋白抑制剂2-[4-(2-羟基乙氧基)-3,5-二甲基苯基]-5,7-二甲氧基喹唑啉-4(3H)-酮的晶型及其制备方法和用途,属于医药领域。所述晶型为晶型CS2、晶型CS8、晶型CS13、晶型CS20、晶型CS1、晶型CS7、晶型CS9、晶型CS11及晶型CS4,可用于制备治疗心血管、胆固醇或脂质相关紊乱疾病的药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)