Search International and National Patent Collections

1. (WO2018103726) CRYSTAL FORM OF BROMODOMAIN PROTEIN INHIBITOR DRUG, PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2018/103726    International Application No.:    PCT/CN2017/115143
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Dec 09 00:59:59 CET 2017
IPC: C07D 413/06
C07D 471/04
A61K 31/517
A61P 9/10
A61P 9/00
A61P 3/10
A61P 5/38
Applicants: CRYSTAL PHARMACEUTICAL (SUZHOU) CO., LTD.
苏州科睿思制药有限公司
Inventors: CHEN, Minhua
陈敏华
ZHANG, Yanfeng
张炎锋
ZHAI, Xiaoting
翟晓婷
YAN, Kaiqiang
鄢楷强
ZHANG, Xiaoyu
张晓宇
Title: CRYSTAL FORM OF BROMODOMAIN PROTEIN INHIBITOR DRUG, PREPARATION METHOD AND USE THEREOF
Abstract:
Provided are a crystal form of a bromodomain protein inhibitor 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one represented by Formula I, a preparation method and a use thereof. The present invention belongs to the field of medicine. The crystal forms are crystal form CS2, crystal form CS8, crystal form CS13, crystal form CS20, crystal form CS1, crystal form CS7, crystal form CS9, crystal form CS11, and crystal form CS4, and can be used to prepare drugs for treating cardiovascular, cholesterol, or lipid-related disorders.