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1. (WO2018103663) SUBSTITUTED PYRAZINECARBOXAMIDE COMPOUND AND COMPOSITION COMPRISING SAME AND USE THEREOF

Pub. No.:    WO/2018/103663    International Application No.:    PCT/CN2017/114810
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Thu Dec 07 00:59:59 CET 2017
IPC: C07D 401/14
A61K 31/497
A61P 35/00
A61P 43/00
Applicants: SHENZHEN TARGETRX, INC.
深圳市塔吉瑞生物医药有限公司
Inventors: WANG, Yihan
王义汉
LI, Huanyin
李焕银
Title: SUBSTITUTED PYRAZINECARBOXAMIDE COMPOUND AND COMPOSITION COMPRISING SAME AND USE THEREOF
Abstract:
Provided in the present invention are a substituted pyrazinecarboxamide compound and a composition comprising the same and the use thereof. The substituted pyrazinecarboxamide compound is a pyrazinecarboxamide compound as represented by formula (I), or a crystal form, a pharmaceutically acceptable salt, a prodrug, a stereoisomer, a hydrate or a solvate thereof. The substituted pyrazinecarboxamide compound and the composition comprising the same disclosed in the present invention have excellent inhibition on an EGFR kinase, and moreover have better pharmacokinetic parametric properties, and can raise the drug concentration of the compound in the animal bodies so as to improve drug efficacy and safety.