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1. (WO2018103654) ARTIFICIAL OVARY AND PREPARATION AND APPLICATION OF SAME

Pub. No.:    WO/2018/103654    International Application No.:    PCT/CN2017/114700
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Thu Dec 07 00:59:59 CET 2017
IPC: C12N 5/071
C12N 5/075
Applicants: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
深圳先进技术研究院
Inventors: ZHANG, Jian
张键
RUAN, Changshun
阮长顺
REN, Peigen
任培根
YANG, Yali
杨雅莉
SUN, Lifeng
孙立峰
ZHAI, Xinyun
翟欣昀
WU, Mingming
吴明明
Title: ARTIFICIAL OVARY AND PREPARATION AND APPLICATION OF SAME
Abstract:
An artificial ovary and a preparation and application of the same. The artificial ovary comprises a biocompatible frame, follicular cells, and a coating mixed liquid, wherein the coating mixed liquid covers the outside of the follicular cells, enters inside voids of the biocompatible frame, and is made from a coated excipient and a biological hormone, and the biocompatible frame is fabricated by 3D printing. The artificial ovary is suitable for composing a research tool for cellular studies of the whole or part of primordial follicles, preantral follicles, and luminal follicles of any species, and is also suitable for a screening model for a factor, a prodrug, and the like related to primordial follicles, preantral follicles, and luminal follicles, and for a prevention or treatment tool for a disease directly or indirectly related to ovarian damage caused by any factor.