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1. (WO2018103501) HUMAN PD-1 KNOCKDOWN SIRNA, RECOMBINANT EXPRESSION CAR-T VECTOR, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/103501 International Application No.: PCT/CN2017/110653
Publication Date: 14.06.2018 International Filing Date: 13.11.2017
IPC:
C12N 15/113 (2010.01) ,C12N 15/867 (2006.01) ,C12N 15/66 (2006.01) ,C12N 5/10 (2006.01) ,A61K 35/17 (2015.01) ,A61K 31/7088 (2006.01) ,A61P 35/00 (2006.01)
Applicants: SHANGHAI UNICAR-THERAPY BIO-MEDICINE TECHNOLOGY CO., LTD[CN/CN]; Room 202, Building No. 4, Halei Road No. 998, Pudong New District Shanghai 201203, CN
Inventors: QI, Wei; CN
YU, Lei; CN
KANG, Liqing; CN
YU, Zhou; CN
Agent: SHANGHAI HONGJING INTELLECTUAL PROPERTY AGENCY(GENERAL PARTNERSHIP); Room A, Floor 21, Science and Technology Jing City West Building, No.668 Beijing East Road Huangpu District, Shanghai 200001, CN
Priority Data:
201611123283.408.12.2016CN
Title (EN) HUMAN PD-1 KNOCKDOWN SIRNA, RECOMBINANT EXPRESSION CAR-T VECTOR, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME
(FR) ARNSI D'INACTIVATION DE PD-1 HUMAIN, VECTEUR DE CAR-T D'EXPRESSION RECOMBINÉE, PROCÉDÉ DE PRÉPARATION ET APPLICATION ASSOCIÉS
(ZH) 敲减人PD-1的siRNA、重组表达CAR-T载体及其构建方法和应用
Abstract: front page image
(EN) Provided are a human PD-1 knockdown siRNA, a recombinant expression CAR-T vector, a preparation method thereof, and an application of the same. A PD-1 knockdown siRNA expression cassette and an siRNA expression product thereof can be applied to a CAR-T therapy of multiple myeloma (MM) for eliminating or alleviating a tumor immune escape mechanism, and in the suppression of an immune escape mechanism in a CAR-T therapy of a tumor, such as pancreatic cancer, brain glioma, and myeloma.
(FR) L'invention concerne un ARNsi d'inactivation de PD-1 humain, un vecteur de CAR-T d'expression recombinée, un procédé de préparation et une application associés. Une cassette d'expression d'ARNsi d'inactivation de PD-1 et un produit d'expression d'ARNsi associé peuvent être appliqués dans un traitement par CAR-T du myélome multiple (MM) afin d'éliminer ou d'atténuer un mécanisme d'évasion immunitaire tumoral, et de supprimer un mécanisme d'évasion immunitaire dans un traitement par CAR-T d'une tumeur, telle que le cancer du pancréas, le gliome cérébral et le myélome.
(ZH) 提供了一种敲减人PD-1的siRNA、重组表达CAR-T载体及其构建方法和应用。其中PD-1敲减siRNA表达框及其siRNA表达产物,不仅可以应用于CAR-T治疗多发性骨髓瘤(MM)中用于消除或减轻肿瘤的免疫逃脱机制,还可应用于抑制CAR-T治疗诸如胰腺癌、脑胶质瘤、骨髓瘤等等类型肿瘤时的免疫逃脱机制。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)