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1. (WO2018103501) HUMAN PD-1 KNOCKDOWN SIRNA, RECOMBINANT EXPRESSION CAR-T VECTOR, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME

Pub. No.:    WO/2018/103501    International Application No.:    PCT/CN2017/110653
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Tue Nov 14 00:59:59 CET 2017
IPC: C12N 15/113
C12N 15/867
C12N 15/66
C12N 5/10
A61K 35/17
A61K 31/7088
A61P 35/00
Applicants: SHANGHAI UNICAR-THERAPY BIO-MEDICINE TECHNOLOGY CO., LTD
上海优卡迪生物医药科技有限公司
Inventors: QI, Wei
祁伟
YU, Lei
俞磊
KANG, Liqing
康立清
YU, Zhou
余宙
Title: HUMAN PD-1 KNOCKDOWN SIRNA, RECOMBINANT EXPRESSION CAR-T VECTOR, PREPARATION METHOD THEREOF, AND APPLICATION OF SAME
Abstract:
Provided are a human PD-1 knockdown siRNA, a recombinant expression CAR-T vector, a preparation method thereof, and an application of the same. A PD-1 knockdown siRNA expression cassette and an siRNA expression product thereof can be applied to a CAR-T therapy of multiple myeloma (MM) for eliminating or alleviating a tumor immune escape mechanism, and in the suppression of an immune escape mechanism in a CAR-T therapy of a tumor, such as pancreatic cancer, brain glioma, and myeloma.