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1. (WO2018102921) ULTRASTABLE GOLD NANOPARTICLES FOR DRUG DELIVERY APPLICATIONS AND SYNTHESIS THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/102921 International Application No.: PCT/CA2017/051474
Publication Date: 14.06.2018 International Filing Date: 06.12.2017
IPC:
A61K 9/14 (2006.01) ,A61K 31/433 (2006.01) ,A61K 31/5575 (2006.01) ,A61K 47/02 (2006.01) ,A61K 47/10 (2017.01) ,A61P 27/06 (2006.01) ,C07C 405/00 (2006.01) ,C07D 285/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
433
Thiadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
557
Eicosanoids, e.g. leukotrienes
5575
having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
06
Antiglaucoma agents or miotics
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
405
Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
285
Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01
Five-membered rings
02
Thiadiazoles; Hydrogenated thiadiazoles
04
not condensed with other rings
10
1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
Applicants:
UNIVERSITÉ LAVAL [CA/CA]; 2320, rue des Bibliothèques, Local 1434 Québec, Québec G1V 0A6, CA
Inventors:
BOISSELIER, Élodie; CA
OUELLETTE, Mathieu; CA
PERNET, Vincent; CA
OMAR, Mahmoud; CA
Agent:
ROBIC LLP; 1001 Square-Victoria, Bloc E - 8th Floor Montréal, Québec H2Z 2B7, CA
Priority Data:
62/430,59206.12.2016US
Title (EN) ULTRASTABLE GOLD NANOPARTICLES FOR DRUG DELIVERY APPLICATIONS AND SYNTHESIS THEREOF
(FR) NANOPARTICULES D'OR ULTRASTABLES DESTINÉES À DES APPLICATIONS D'ADMINISTRATION DE MÉDICAMENTS ET LEUR SYNTHÈSE
Abstract:
(EN) Herein presented are gold nanoparticles (AuNPs) used for the transport of medications to mucous membranes. The AuNPs are ultra-stable in that they withstand freeze-drying and heating treatments without noticeable change in their structure. In addition, they interact with mucous membranes, and therefore allow transport of certain drugs to these mucous membranes, allowing higher exposure time of the drugs, hence decreased dosing schedule of administration.
(FR) La présente invention concerne des nanoparticules d'or (AuNPs) utilisées pour le transport de médications vers des membranes muqueuses. Les AuNPs sont ultra stables en ce qu'elles résistent à des traitements de lyophilisation et de chauffage sans changement sensible de leur structure. De plus, elles entrent en interaction avec les membranes muqueuses, et permettent par conséquent le transport de certains médicaments vers les membranes muqueuses, ce qui permet un temps d'exposition aux médicaments plus élevé, d'où une réduction du schéma posologique d'administration.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)