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1. (WO2018102920) THIENOISOQUINOLINES AND THEIR DERIVATIVES FOR THE TREATMENT OF CANCER
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Pub. No.: WO/2018/102920 International Application No.: PCT/CA2017/051473
Publication Date: 14.06.2018 International Filing Date: 06.12.2017
IPC:
C07D 495/04 (2006.01) ,A61K 31/4436 (2006.01) ,A61P 35/00 (2006.01) ,C07D 495/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4436
containing a heterocyclic ring having sulfur as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
Applicants:
VALORBEC, SEC [CA/CA]; 355, rue Peel Bureau 503 Montréal, Québec H3C 2G9, CA
Inventors:
FORGIONE, Pasquale; CA
PIEKNY, Alisa Julienne; CA
JAUNKY, Dilan Boodhai; CA
CHEN, Fei; CA
LIU, Jiang Tian; CA
Agent:
BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.; 40th Floor 40 King Street West Toronto, Ontario M5H 3Y2, CA
Priority Data:
62/430,38706.12.2016US
Title (EN) THIENOISOQUINOLINES AND THEIR DERIVATIVES FOR THE TREATMENT OF CANCER
(FR) THIÉNOISOQUINOLÉINES ET LEURS DÉRIVÉS POUR LE TRAITEMENT DU CANCER
Abstract:
(EN) The present disclosure relates to fused N-arylsulfonamidyl-thienoisoquinoline compounds, derivatives and pharmaceutical compositions thereof, and methods and uses in inhibiting cancer cell growth, along with a supplemental anti-cancer agent. Centrosome targeting and microtubule depolymerisation are attractive in designing the present chemotherapeutic compounds. The various diseases and conditions treated include various types of cell cancers, and in vitro inhibition.
(FR) La présente invention concerne des composés de N-arylsulfonamidyl-thiénoisoquinoléine fusionnés, des dérivés et des compositions pharmaceutiques de ceux-ci, et des procédés et des utilisations dans l'inhibition de la croissance de cellules cancéreuses, conjointement avec un agent anticancéreux supplémentaire. Le ciblage de centrosomes et la dépolymérisation de microtubules sont attractifs dans la conception des présents composés chimiothérapeutiques. Les diverses maladies et affections traitées comprennent divers types de cancers cellulaires, et une inhibition in vitro.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)