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1. (WO2018102881) COMPOSITIONS AND METHODS FOR MATURATION OF OOCYTES IN VITRO
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Pub. No.: WO/2018/102881 International Application No.: PCT/AU2017/051354
Publication Date: 14.06.2018 International Filing Date: 08.12.2017
Chapter 2 Demand Filed: 04.10.2018
IPC:
C12N 5/075 (2010.01) ,C07K 14/535 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
075
Oocytes; Oogonia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
53
Colony-stimulating factor (CSF)
535
Granulocyte CSF; Granulocyte-macrophage CSF
Applicants:
THE UNIVERSITY OF ADELAIDE [AU/AU]; North Terrace Adelaide, South Australia 5000, AU
Inventors:
NOTTLE, Mark, Brenton; AU
Agent:
PHILLIPS ORMONDE FITZPATRICK; Level 16, 333 Collins Street Melbourne, Victoria 3000, AU
Priority Data:
201690509609.12.2016AU
Title (EN) COMPOSITIONS AND METHODS FOR MATURATION OF OOCYTES IN VITRO
(FR) COMPOSITIONS ET PROCÉDÉS DE MATURATION D'OVOCYTES IN VITRO
Abstract:
(EN) The present invention relates to culture media for oocytes and uses thereof. Specifically, media for culturing an oocyte in vitro are disclosed, wherein said media comprise granulocyte macrophage-colony stimulating factor (GM-CSF). The presence of GM-CSF in the media increases the maturation and/or developmental competence of the oocyte making it suitable for use in subsequent assisted reproductive technologies. Methods for increasing the maturation and/or developmental competence of an oocyte are also disclosed.
(FR) La présente invention concerne des milieux de culture pour des ovocytes et des utilisations correspondantes. Plus particulièrement, l'invention concerne des milieux pour la culture d'un ovocyte in vitro, lesdits milieux comprenant un facteur stimulant les colonies de granulocytes et de macrophages (GM-CSF). La présence du GM-CSF dans les milieux augmente la maturation et/ou la compétence de développement de l'ovocyte, ce qui le rend approprié pour une utilisation dans des technologies de reproduction assistée subséquentes. L'invention concerne également des procédés pour augmenter la maturation et/ou la compétence de développement d'un ovocyte.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)