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1. (WO2018102857) DETERMINING CANCER RESPONSIVENESS TO TREATMENT

Pub. No.:    WO/2018/102857    International Application No.:    PCT/AU2017/050609
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Sat Jun 17 01:59:59 CEST 2017
IPC: C12Q 1/68
A61K 31/495
Applicants: QUEENSLAND UNIVERSITY OF TECHNOLOGY
Inventors: RICHARD, Derek
Title: DETERMINING CANCER RESPONSIVENESS TO TREATMENT
Abstract:
Provided are methods of treatment for particular cancers and determining response to therapy with an anti-cancer agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break, said methods including determining a property of an NPM1 nucleic acid or protein, such as an expression level, a mutational status and/or a subcellular location thereof. Also provided is a method of treating cancer which includes administering an agent that inhibits or prevents the expression and/or an activity of an NPM1 nucleic acid and/or protein and an anti-cancer agent that inhibits activity of an enzyme that mediates repair of a DNA strand break, such as a PARP inhibitor.