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1. (WO2018102854) TREATMENT OF OBESITY AND EATING DISORDERS

Pub. No.:    WO/2018/102854    International Application No.:    PCT/AU2017/000262
Publication Date: Fri Jun 15 01:59:59 CEST 2018 International Filing Date: Thu Dec 07 00:59:59 CET 2017
IPC: A61K 38/19
A61K 38/22
A61K 39/395
A61P 3/04
A61P 1/14
Applicants: ST VINCENT'S HOSPITAL SYDNEY LIMITED
Inventors: BREIT, Samuel Norbert
Title: TREATMENT OF OBESITY AND EATING DISORDERS
Abstract:
Methods for controlling body weight and/or appetite in a subject are disclosed. In some embodiments, the methods involve administering to an overweight or obese subject an effective amount of a first agent comprising MIC-1, a MIC- 1 agonist and/or a MIC-1-inducing agent, and a second agent comprising leptin and/or a leptin agonist, for the purpose of achieving weight loss. In other embodiments, the methods involve administering to an anorexic or cachectic subject an effective amount of a MIC-1-inhibiting agent and a leptin-inhibiting agent, for the purpose of increasing body weight and/or appetite in a subject.