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1. (WO2018102822) MULTI-PHOTON ENDOMICROSCOPE FOR VERTICAL CROSS-SECTIONAL IMAGING

Pub. No.:    WO/2018/102822    International Application No.:    PCT/US2017/064539
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Tue Dec 05 00:59:59 CET 2017
IPC: A61B 6/00
G01N 21/64
G01N 33/483
G02B 3/00
Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Inventors: OLDHAM, Ken
CHOI, Jongsoo
DUAN, Xiyu
WANG, Thomas, D.
LI, Haijun
Title: MULTI-PHOTON ENDOMICROSCOPE FOR VERTICAL CROSS-SECTIONAL IMAGING
Abstract:
A multi-photon optical probe includes a probe housing, a lateral scanning stage coupled to a lateral mirror assembly and a remote axial scanning stage coupled to an axial mirror assembly. The lateral scanning stage is adapted to scan output laser energy over a planar scan area of the sample by moving the lateral mirror assembly. The axial scanning stage is adapted to scan the output laser energy over a vertical depth range of the sample, which, combined with the planar scan area, forms a 3-dimensional volume. A controller operates in conjunction with a number of remote actuating legs coupled to the axial mirror assembly in order to provide level imaging plane which in turn provides for a clear scanned image.