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1. (WO2018102808) REDOX PROBING FOR CHEMICAL INFORMATION

Pub. No.:    WO/2018/102808    International Application No.:    PCT/US2017/064485
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Tue Dec 05 00:59:59 CET 2017
IPC: G01N 27/327
Applicants: UNIVERSITY OF MARYLAND, COLLEGE PARK
UNIVERSITY OF MARYLAND, BALTIMORE
Inventors: KIM, Dr. Eunkyoung
PAYNE, Dr. Gregory F.
KANG, Dr. Mijeong
GHODSSI, Dr. Reza
WINKLER, Mr. Thomas E.
BANIS, Mr. George
KITCHEN, Mr. Christopher
KELLY, Dr. Deanna L.
BENTLEY, Dr. William E.
Title: REDOX PROBING FOR CHEMICAL INFORMATION
Abstract:
Methods are provided that allow global access to redox-based molecular information by coupling electrochemical measurements with signal processing approaches. More specifically, the disclosure provides methods that rely on the use of redox probes to assay samples for redox activities that act to exchange electrons with the probe thereby generating detectable optical and electrochemical signature signals that can then be assigned to a sample feature of interest. In particular embodiments, the disclosed assay methods are useful for diagnosis and prognosis of disorders, such as schizophrenia, that are found to be associated with a specific redox-based signature within a subject sample.