Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018102786) METHODS FOR MODULATION OF CAR-T CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/102786 International Application No.: PCT/US2017/064363
Publication Date: 07.06.2018 International Filing Date: 01.12.2017
IPC:
A61K 39/395 (2006.01) ,A61K 39/44 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44
Antibodies bound to carriers
Applicants:
JUNO THERAPEUTICS, INC. [US/US]; 400 Dexter Ave. N Suite 1200 Seattle, WA 98109, US
Inventors:
ALBERTSON, Tina; US
Agent:
POTTER, Karen; US
AIKEN, Charity; US
BANKO, Max; US
ARJOMAND, Mehran; US
Priority Data:
62/429,74003.12.2016US
62/444,78410.01.2017US
62/492,95001.05.2017US
62/514,77702.06.2017US
62/515,51205.06.2017US
62/549,39123.08.2017US
62/580,41401.11.2017US
Title (EN) METHODS FOR MODULATION OF CAR-T CELLS
(FR) PROCÉDÉS DE MODULATION DE LYMPHOCYTES T MODIFIÉS PAR CAR
Abstract:
(EN) Provided herein are methods of modulating, in vivo, cells engineered with a recombinant receptor, such as a T cell receptor (TCR) or chimeric antigen receptor (CAR). In some embodiments, the methods include disrupting an area in the subject in which the cells are present or likely to be present or were present or were likely to be present, such as a lesion, including a tumor. In some embodiments, the disruption alters the environment of the lesion, e.g. tumor microenvironment. In some embodiments, the disruption is a biopsy. In some aspects, the provided methods result in increased expansion, and, in some cases, a more robust and durable response, of the engineered cells after carrying out the disruption.
(FR) L'invention concerne des procédés de modulation, in vivo, de cellules modifiées par un récepteur recombinant, tel qu'un récepteur de lymphocytes T (TCR) ou un récepteur antigénique chimérique (CAR). Dans certains modes de réalisation, les procédés consistent à perturber chez le sujet une zone dans laquelle les cellules sont présentes ou susceptibles d'être présentes ou ont été présentes ou étaient vraisemblablement présentes, telle qu'une lésion, y compris une tumeur. Dans certains modes de réalisation, la perturbation modifie l'environnement de la lésion, par exemple le micro-environnement tumoral. Dans certains modes de réalisation, la perturbation est une biopsie. Selon certains aspects, les procédés selon l'invention entraînent une expansion accrue, et, dans certains cas, une réponse plus robuste et durable, des cellules modifiées après la perturbation.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)