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1. (WO2018102785) METHODS AND COMPOSITIONS FOR USE OF THERAPEUTIC T CELLS IN COMBINATION WITH KINASE INHIBITORS

Pub. No.:    WO/2018/102785    International Application No.:    PCT/US2017/064362
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Sat Dec 02 00:59:59 CET 2017
IPC: A61K 35/00
C07K 14/00
C07K 16/28
A61K 45/06
A61K 31/505
A61K 31/506
A61K 39/395
A61K 35/17
Applicants: JUNO THERAPEUTICS, INC.
PORTS, Michael
QIN, Jim
SALMON, Ruth
BATUREVYCH, Oleksandr
Inventors: PORTS, Michael
QIN, Jim
SALMON, Ruth
BATUREVYCH, Oleksandr
Title: METHODS AND COMPOSITIONS FOR USE OF THERAPEUTIC T CELLS IN COMBINATION WITH KINASE INHIBITORS
Abstract:
The present disclosure relates to methods, compositions and uses involving immunotherapies and inhibitors of a target protein tyrosine kinase in which the kinase is not IL-2-inducible T cell kinase (ITK) and/or is selected from Bruton's tyrosine kinase (BTK), tec protein tyrosine kinase (TEC), BMX non-receptor tyrosine kinase (Etk), TXK tyrosine kinase (TXK) and/or receptor tyrosine-protein kinase ErbB4 (ErbB4). The provided methods, compositions and uses include administration of one or more such inhibitor with another agent, such as an immunotherapeutic agent targeting T cells and/or genetically engineered T cells, such as CAR-expressing T cells. Also provided are methods of manufacturing engineered cells, cells, compositions, methods of administration, nucleic acids, articles of manufacture and kits. In some aspects, features of the methods and cells provide for improved activity, efficacy, persistence, expansion and/or proliferation of T cells for adoptive cell therapy or endogenous T cells recruited by immunotherapeutic agents.