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1. (WO2018102763) INFRARED ASSAY DETECTING SECONDARY STRUCTURE PROFILES OF ALPHA-SYNUCLEIN

Pub. No.:    WO/2018/102763    International Application No.:    PCT/US2017/064332
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Sat Dec 02 00:59:59 CET 2017
IPC: A61K 39/00
A61K 39/395
A61K 49/00
A61P 25/16
C07K 16/18
G01N 21/35
Applicants: PROTHENA BIOSCIENCES LIMITED
BARBOUR, Robin
Inventors: BARBOUR, Robin
Title: INFRARED ASSAY DETECTING SECONDARY STRUCTURE PROFILES OF ALPHA-SYNUCLEIN
Abstract:
The invention provides an infrared assay which allows the secondary structure analysis of alpha-synuclein from complex fluids like serum, blood plasma or cerebrospinal fluid without prior isolation, concentration or pretreatment. The secondary structure profile provides an indication of the proportion of alpha-synuclein in aggregated form and/or extent of aggregation of alpha-synuclein in aggregated form.