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1. (WO2018102668) FUSION PROTEINS FOR SELECTIVELY DEPLETING ANTIGEN-SPECIFIC ANTIBODIES
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Pub. No.: WO/2018/102668 International Application No.: PCT/US2017/064186
Publication Date: 07.06.2018 International Filing Date: 01.12.2017
IPC:
A61K 39/00 (2006.01) ,A61K 39/395 (2006.01) ,A61K 38/38 (2006.01) ,A61K 38/40 (2006.01) ,A61P 37/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
38
Albumins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
40
Transferrins, e.g. lactoferrins, ovotransferrins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
Applicants:
THE TEXAS A&M UNIVERSITY SYSTEM [US/US]; 3369 Tamu College Station, TX 77843-3369, US
Inventors:
OBER, Elizabeth Sally Ward; US
DEVANABOYINA, Venkata Siva Charan; US
OBER, Raimund Johannes; US
Agent:
LECOINTE, Michelle; US
Priority Data:
62/429,36702.12.2016US
Title (EN) FUSION PROTEINS FOR SELECTIVELY DEPLETING ANTIGEN-SPECIFIC ANTIBODIES
(FR) PROTÉINES DE FUSION POUR L’APPAUVRISSANT SÉLECTIVE D'ANTICORPS SPÉCIFIQUES D'UN ANTIGÈNE
Abstract:
(EN) The present disclosure includes a fusion protein, called a "Seldeg", including a targeting component that specifically binds to a cell surface receptor or other cell surface molecule at near-neutral pH, and an antigen component fused directly or indirectly to the targeting component. The antigen component is configured to specifically bind a target antigen-specific antibody. The present disclosure also includes a method of depleting a target antigen-specific antibody from a patient by administering to the patient a Seldeg having an antigen component configured to specifically bind the target antigen-specific antibody.
(FR) La présente invention comprend une protéine de fusion, appelée "Seldeg", comprenant un composant de ciblage qui se lie spécifiquement à un récepteur de surface cellulaire ou à une autre molécule de surface cellulaire à un pH presque neutre, et un composant antigène fusionné directement ou indirectement au composant de ciblage. Le composant antigène est configuré pour se lier spécifiquement à un anticorps spécifique d'un antigène cible. La présente invention concerne également un procédé d'appauvrissement d'un anticorps spécifique d'un antigène cible d'un patient par l'administration au patient d'une Seldeg ayant un composant antigène configuré pour se lier spécifiquement à l'anticorps spécifique d'antigène cible.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)