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1. (WO2018102597) METHODS OF TREATING INFLAMMATORY CONDITIONS
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Pub. No.: WO/2018/102597 International Application No.: PCT/US2017/064041
Publication Date: 07.06.2018 International Filing Date: 30.11.2017
IPC:
C07K 16/24 (2006.01) ,C07K 16/28 (2006.01) ,A61K 39/00 (2006.01) ,C07K 14/715 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
715
for cytokines; for lymphokines; for interferons
Applicants:
REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road Tarrytown, New York 10591, US
Inventors:
ORENGO, Jamie M.; US
ALLINNE, Jeanne; US
MURPHY, Andrew J.; US
YANCOPOULOS, George D.; US
Agent:
TERMES, Lance A.; US
Priority Data:
62/428,63401.12.2016US
62/473,73820.03.2017US
62/567,31803.10.2017US
Title (EN) METHODS OF TREATING INFLAMMATORY CONDITIONS
(FR) MÉTHODES DE TRAITEMENT D'ÉTATS INFLAMMATOIRES
Abstract:
(EN) The present invention provides methods for treating inflammatory diseases, or conditions associated with, or resulting in part from, elevated levels of IL-33 and IL-4, in particular inflammatory lung disorders. The methods of the present invention comprise administering to a subject in need thereof one or more therapeutically effective doses of an IL-33 antagonist alone or in combination with one or more therapeutically effective doses of an IL-4R antagonist. In certain embodiments, the methods of the present invention include use of the antagonists to treat any inflammatory disease or condition mediated in part by enhanced IL-33-mediated signaling and IL-4-mediated signaling.
(FR) La présente invention concerne des méthodes destinées à traiter les maladies ou états inflammatoires associés à des taux élevés d'IL-33 et d'IL-4 ou résultant en partie de ceux-ci, en particulier les affections pulmonaires inflammatoires. Les méthodes selon l'invention comprennent l'administration à un sujet en ayant besoin d'une ou de plusieurs doses thérapeutiquement efficaces d'un antagoniste d'IL-33 seul ou en association avec une ou plusieurs doses thérapeutiquement efficaces d'un antagoniste d'IL-4R. Dans certains modes de réalisation, les méthodes comprennent l'utilisation d'antagonistes pour traiter toute maladie ou état inflammatoire en partie médié(e) par une signalisation médiée par IL-33 et une signalisation médiée par IL-4 accrues.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)