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1. (WO2018102589) ANTI-HRS ANTIBODIES AND COMBINATION THERAPIES FOR TREATING CANCERS

Pub. No.:    WO/2018/102589    International Application No.:    PCT/US2017/064025
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Fri Dec 01 00:59:59 CET 2017
IPC: A61K 38/43
A61K 49/16
C07K 16/40
C12P 21/08
G01N 33/563
Applicants: ATYR PHARMA, INC.
Inventors: ADAMS, Ryan Andrew
BURMAN, Luke
CHONG, Yeeting
KING, David
MENDLEIN, John D.
GREENE, Leslie Nangle
OGILVIE, Kathleen
RAUCH, Kaitlyn
Title: ANTI-HRS ANTIBODIES AND COMBINATION THERAPIES FOR TREATING CANCERS
Abstract:
Provided are antibodies that specifically bind to human histidyl-tRNA synthetase and related therapeutic compositions and methods for treating cancer, including as standalone therapies or in combination with cancer immunotherapies, for example, immune checkpoint modulators such as PD-1 inhibitors.