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1. (WO2018102485) TETRACYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/102485    International Application No.:    PCT/US2017/063831
Publication Date: 07.06.2018 International Filing Date: 30.11.2017
IPC:
C07D 487/16 (2006.01), C07D 498/16 (2006.01), A61P 31/18 (2006.01), A61K 31/4985 (2006.01), A61K 31/5365 (2006.01), A61K 31/424 (2006.01)
Applicants: MERCK SHARP & DOHME CORP. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US).
GRAHAM, Thomas, H. [US/US]; (US) (US only).
YU, Tao [CN/US]; (US) (US only).
ZHANG, Yonglian [CN/US]; (US) (US only).
MCCAULEY, John, A. [US/US]; (US) (US only)
Inventors: GRAHAM, Thomas, H.; (US).
YU, Tao; (US).
ZHANG, Yonglian; (US).
MCCAULEY, John, A.; (US)
Common
Representative:
MERCK SHARP & DOHME CORP.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 (US)
Priority Data:
62/429,470 02.12.2016 US
Title (EN) TETRACYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS
(FR) COMPOSÉS HÉTÉROCYCLIQUES TÉTRACYCLIQUES UTILES EN TANT QU'INHIBITEURS DE L'INTÉGRASE DU VIH
Abstract: front page image
(EN)The present invention relates to Tetracyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein A, X, R1, R2, R3 and R7 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
(FR)La présente invention concerne des composés hétérocycliques tétracycliques de formule (I) : (I) et leurs sels ou promédicaments pharmaceutiquement acceptables, dans laquelle, A, X, R1, R2, R3 et R7 sont tels que définis dans la description. La présente invention porte également sur des compositions comprenant au moins un composé hétérocyclique tétracyclique et sur des procédés d'utilisation des composés hétérocycliques tétracycliques pour le traitement ou la prévention d'une infection à VIH chez un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)