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1. (WO2018102455) METHODS FOR THE TREATMENT OF CANCER
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Pub. No.: WO/2018/102455 International Application No.: PCT/US2017/063779
Publication Date: 07.06.2018 International Filing Date: 29.11.2017
IPC:
A61K 9/20 (2006.01) ,A61K 9/48 (2006.01) ,A61K 31/517 (2006.01) ,A61P 35/00 (2006.01) ,C07C 55/08 (2006.01) ,C07D 239/88 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
55
Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
02
Dicarboxylic acids
08
Malonic acid
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70
condensed with carbocyclic rings or ring systems
72
Quinazolines; Hydrogenated quinazolines
86
with hetero atoms directly attached in position 4
88
Oxygen atoms
Applicants:
IGNYTA, INC. [US/US]; 4545 Towne Centre Ct. San Diego, California 92121, US
Inventors:
LIM, Jonathan Ee-Ren; US
MULTANI, Pratik S.; US
LANDIN, Richard; US
PATEL, Rupal A.; US
OLIVER, Jennifer Wright; US
Agent:
LOMPREY, Jeffrey R.; US
LEE-DUTRA, Alice; US
RAO, Photon; US
Priority Data:
62/428,94701.12.2016US
Title (EN) METHODS FOR THE TREATMENT OF CANCER
(FR) MÉTHODES DE TRAITEMENT DU CANCER
Abstract:
(EN) Disclosed herein are methods of treating cancer in a subject, wherein the subject is known to possess at least one genetic alteration in RET, comprising administering to the subject a therapeutically effective amount of N-[3-[(6,7-dimethoxy-4- quinazolinyl)oxy]phenyl]-N'-[5-(2,2,2-trifluoro-l, l-dimethylethyl)-3-isoxazolyl]-urea, or a pharmaceutically acceptable salt thereof.
(FR) L'invention concerne des méthodes de traitement du cancer chez un sujet, le sujet étant connu pour présenter au moins une altération génétique dans RET, lesdites méthodes comprenant l'administration au sujet d'une quantité thérapeutiquement efficace de N-[3-[(6,7-diméthoxy-4-quinazolinyl)oxy]phényl]-N'-[5- (2,2,2-trifluoro-l, l-diméthyléthyl)-3-isoxazolyle]-urée, ou un sel pharmaceutiquement acceptable de celui-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)