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1. (WO2018102453) SUBSTITUTED PYRAZOLE COMPOUNDS AND METHODS OF USING THEM FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES
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Pub. No.: WO/2018/102453 International Application No.: PCT/US2017/063774
Publication Date: 07.06.2018 International Filing Date: 29.11.2017
IPC:
C07D 417/04 (2006.01) ,C07D 417/14 (2006.01) ,C07D 471/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
BANTAM PHARMACEUTICAL, LLC [US/US]; 505 Park Avenue Suite 401 New York, NY 10022, US
Inventors:
SIDDIQUI, Arshad, M.; US
CIBLAT, Stephane; CA
DERY, Martin; CA
CONSTANTINEUA-FORGET, Lea; CA
GRAND-MAITRE, Chantal; CA
BRUNEAU-LATOUR, Nicolas; CA
SHIPPS, Gerald, W.; US
COOPER, Alan, B.; US
OZA, Vibha; US
KOSTURA, Matthew, W.; US
LUTHER, Michael; US
LEVINE, Jedd; US
Agent:
SUGGS, James, V.; US
Priority Data:
62/428,27130.11.2016US
Title (EN) SUBSTITUTED PYRAZOLE COMPOUNDS AND METHODS OF USING THEM FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES
(FR) COMPOSÉS PYRAZOLE SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION POUR LE TRAITEMENT DE MALADIES HYPERPROLIFÉRATIVES
Abstract:
(EN) Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.
(FR) L'invention concerne des composés utiles, par exemple, dans des procédés de traitement de troubles hyperprolifératifs tels que le cancer, des procédés d'arrêt du cycle cellulaire dans des cellules cancéreuses, des procédés d'inhibition de la synthèse de glutathion dans des cellules cancéreuses, et des composés associés pour une utilisation et des utilisations dans des médicaments. Dans certains modes de réalisation, les procédés, les utilisations et les composés sont fournis en référence à des composés des formules structurales (Ia), (Ib), (Ic), (Id) et (Ie), dans lesquelles R1, L1, L2, Q, L3, R3, L4, R4, L5 et R5 sont tels que décrits dans la description. Dans certains modes de réalisation, les composés de l'invention sont particulièrement actifs contre des cancers ayant un gène KRAS mutant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)