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1. (WO2018102452) METHODS OF USING SUBSTITUTED PYRAZOLE AND PYRAZOLE COMPOUNDS AND FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES
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Pub. No.: WO/2018/102452 International Application No.: PCT/US2017/063772
Publication Date: 07.06.2018 International Filing Date: 29.11.2017
IPC:
A61K 31/427 (2006.01) ,C07D 417/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
Applicants:
BANTAM PHARMACEUTICAL, LLC [US/US]; 505 Park Avenue Suite 401 New York, NY 10022, US
Inventors:
SIDDIQUI, M. Arshad; US
CIBLAT, Stephane; CA
CONSTANTINEAU-FORGET, Lea; CA
GRAND-MAITRE, Chantal; CA
GUO, Xiangyu, Jr.; CA
SRIVASTAVA, Sanjay; CA
SHIPPS, Gerald W.; US
COOPER, Alan B.; US
OZA, Vibha; US
KOSTURA, Matthew; US
LUTHER, Michael; US
LEVINE, Jedd; US
Agent:
SUGGS, James V.; US
Priority Data:
62/428,27430.11.2016US
Title (EN) METHODS OF USING SUBSTITUTED PYRAZOLE AND PYRAZOLE COMPOUNDS AND FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES
(FR) MÉTHODES D'UTILISATION DE COMPOSÉS PYRAZOLE ET PYRAZOLE SUBSTITUÉS POUR LE TRAITEMENT DE MALADIES HYPERPROLIFÉRATIVES
Abstract:
(EN) Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by "a", R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.
(FR) L'invention concerne des méthodes de traitement de troubles hyperprolifératifs tels que le cancer, des méthodes d'arrêt du cycle cellulaire dans les cellules cancéreuses, des méthodes d'inhibition de la synthèse du glutathion dans les cellules cancéreuses, et des composés associés destinés à être utilisés dans des médicaments. Dans certains modes de réalisation, les méthodes, utilisations et composés sont fournis en référence à des composés de formule développée (I), dans laquelle X1, X2, Z1, Z2, le système cyclique désigné par « a », R1, L1, L2, Q, L3, R3, L4, R4, L5, et R5 sont tels que décrits dans la description. Dans certains modes de réalisation, les composés décrits dans la présente description sont particulièrement actifs contre des cancers ayant un gène KRAS mutant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)