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1. (WO2018102412) A PERILLYL ALCOHOL-3 BROMOPYRUVATE CONJUGATE AND METHODS OF TREATING CANCER
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Pub. No.: WO/2018/102412 International Application No.: PCT/US2017/063706
Publication Date: 07.06.2018 International Filing Date: 29.11.2017
IPC:
A01N 43/52 (2006.01) ,A61K 31/045 (2006.01) ,A61K 31/05 (2006.01) ,A61K 31/27 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48
having rings with two nitrogen atoms as the only ring hetero atoms
50
1,3-Diazoles; Hydrogenated 1,3-diazoles
52
condensed with carbocyclic rings, e.g. benzimidazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05
Phenols
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
27
of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
Applicants:
NEONC TECHNOLOGIES, INC. [US/US]; 8335 Sunset Blvd. Suite 240 Los Angeles, CA 90069, US
Inventors:
CHEN, Thomas; US
Agent:
DAVITZ, Michael, A.; US
KRAMER, Carney, Bonnie; US
LEASON, David; US
ELLIS, Edward, J.; US
CHENG, Susie; US
Priority Data:
62/428,28630.11.2016US
Title (EN) A PERILLYL ALCOHOL-3 BROMOPYRUVATE CONJUGATE AND METHODS OF TREATING CANCER
(FR) CONJUGUÉ D'ALCOOL PÉRILLYLIQUE-3-BROMOPYRUVATE ET MÉTHODES DE TRAITEMENT DE CANCER
Abstract:
(EN) NEO218 (3-bromo-2-oxo-propionic acid 4-isopropenyl-cyclohex-l-enylmethyI ester), (see formula I), is a novel molecule that was generated by covalent fusion of two unrelated agents: 3- bromopyruvate (3-BF; an alkylating agent that Inhibits cancer cell metabolism) and perillyi alcohol (POH; a natural monoterpene with anticancer properties ). Methods of synthesizing NBO218, pharmaceutical compositions comprising NBO218 and methods of treating cancer using NBO218 are also disclosed.
(FR) Le NEO218 (acide 3-bromo-2-oxo-propionique 4-isopropényl-cyclohex-l-énylméthyl ester), (voir formule I), est une nouvelle molécule qui a été générée par fusion covalente de deux agents non apparentés : le 3-bromopyruvate (3-BF; un agent alkylant qui inhibe le métabolisme des cellules cancéreuses) et l'alcool périllylique (POH; un monoterpène naturel ayant des propriétés anticancéreuses). L'invention concerne également des méthodes de synthèse de NBO218, des compositions pharmaceutiques comprenant le NBO218 et des méthodes de traitement de cancer à l'aide du NBO218.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)