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1. (WO2018102397) EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS

Pub. No.:    WO/2018/102397    International Application No.:    PCT/US2017/063681
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Thu Nov 30 00:59:59 CET 2017
IPC: A61K 9/133
A61K 9/127
A61K 9/10
Applicants: PURETECH HEALTH LLC
Inventors: BOLEN, Joseph
BONNER, Daniel Kenneth
FERREIRA, Lisa V.
KRUMOVA, Katerina
JANTZ, John
MUTAMBA, James Tendai
SHYAM, Rishab R.
Title: EXOSOMES FOR DELIVERY OF THERAPEUTIC AGENTS
Abstract:
The present invention provides exosomes as drug delivery vehicles, compositions comprising a therapeutic agent encapsulated within such exosomes, methods of producing such exosomes and compositions thereof, as well as methods of delivering such exosomes and compositions to a specific patient tissue or organ. The present invention also provides methods of treating a disease, disorder, or condition such as cancer, an inflammatory disease, an infectious disease, an allergic disease, or an autoimmune disease, comprising administering to a patient in need thereof a provided therapeutic-loaded exosome or a pharmaceutical composition thereof.