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1. (WO2018102384) PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS

Pub. No.:    WO/2018/102384    International Application No.:    PCT/US2017/063661
Publication Date: Fri Jun 08 01:59:59 CEST 2018 International Filing Date: Thu Nov 30 00:59:59 CET 2017
IPC: C07D 491/08
A61K 31/519
C07D 487/04
C07D 487/08
A61P 9/06
Applicants: GILEAD SCIENCES, INC.
Inventors: ELZEIN, Elfatih
KALLA, Rao V.
KOLTUN, Dmitry
LI, Xiaofen
PARKHILL, Eric Q.
PERRY, Thao
SIMONOVICH, Scott Preston
ZABLOCKI, Jeff
ZIEBENHAUS, Christopher Allen
Title: PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS
Abstract:
The present disclosure relates to compounds that are CaM Kinase inhibitors and to their use in the treatment of various disease states, including atrial fibrillation and myocardial infarction. In particular embodiments, the general structure of the compounds is given by Formula I: (I) wherein R1, R2, R3, R4, R5, R6, R9 and R10 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.