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1. (WO2018102384) PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/102384 International Application No.: PCT/US2017/063661
Publication Date: 07.06.2018 International Filing Date: 29.11.2017
IPC:
C07D 491/08 (2006.01) ,A61K 31/519 (2006.01) ,C07D 487/04 (2006.01) ,C07D 487/08 (2006.01) ,A61P 9/06 (2006.01)
Applicants: GILEAD SCIENCES, INC.[US/US]; 333 Lakeside Drive Foster City, CA 94404, US
Inventors: ELZEIN, Elfatih; US
KALLA, Rao V.; US
KOLTUN, Dmitry; US
LI, Xiaofen; US
PARKHILL, Eric Q.; US
PERRY, Thao; US
SIMONOVICH, Scott Preston; US
ZABLOCKI, Jeff; US
ZIEBENHAUS, Christopher Allen; US
Agent: GINAH, Francis O.; US
AMIRGHOLIZADEH, Tashica W.; US
BARRON, Briana R.; US
BOSS, Brandon; US
CAPPS, Kevin J.; US
CHOI, Lydia B.; US
DAMMANN, Yu-Ming; US
EDWARDS, Mary J.; US
GRESSLER, Donna; US
HARTRUM, J. Elin; US
HUTCHISON, Andrea; US
LECHNER, Jolie D.; US
LO, Karen; US
MARQUART, Timothy A.; US
MORGAN, Lorie Ann; US
POLSTER, Philip B.; US
RICE, Katharine R.; US
SILVER, Joel; US
Priority Data:
62/428,39730.11.2016US
Title (EN) PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS
(FR) DÉRIVÉS DE PYRAZOLOPYRIMIDINE EN TANT QU'INHIBITEURS DE KINASE CAM
Abstract: front page image
(EN) The present disclosure relates to compounds that are CaM Kinase inhibitors and to their use in the treatment of various disease states, including atrial fibrillation and myocardial infarction. In particular embodiments, the general structure of the compounds is given by Formula I: (I) wherein R1, R2, R3, R4, R5, R6, R9 and R10 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
(FR) La présente invention concerne des composés qui sont des inhibiteurs de kinase CaM et leur utilisation dans le traitement de divers états pathologiques, dont la fibrillation auriculaire et l'infarctus du myocarde. Selon des modes de réalisation particuliers, la structure des composés est représentée par la formule I : (I), dans laquelle, R1, R2, R3, R4, R5, R6, R9 et R10 sont tels que définis dans la description. L'invention concerne également des procédés pour la préparation et l'utilisation des composés et des compositions pharmaceutiques les contenant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)