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|1. (WO2018102384) PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS|
|Applicants:||GILEAD SCIENCES, INC.
KALLA, Rao V.
PARKHILL, Eric Q.
SIMONOVICH, Scott Preston
ZIEBENHAUS, Christopher Allen
|Title:||PYRAZOLOPYRIMIDINE DERIVATIVES AS CAM KINASE INHIBITORS|
The present disclosure relates to compounds that are CaM Kinase inhibitors and to their use in the treatment of various disease states, including atrial fibrillation and myocardial infarction. In particular embodiments, the general structure of the compounds is given by Formula I: (I) wherein R1, R2, R3, R4, R5, R6, R9 and R10 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.